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Identification and Investigation of Variants Associated with Bipolar Disorder and Schizophrenia

Publications

1. Folding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteins.
   Da Paula AC, Sousa M, Xu Z, Dawson ES, Boyd AC, Sheppard DN, Amaral MD.
   J Biol Chem. 2010 Aug 27;285(35):27033-44. Epub 2010 Jun 15
2. Sputum and serum calprotectin are useful biomarkers during CF exacerbation.
   Gray RD, Imrie M, Boyd AC, Porteous D, Innes JA, Greening AP.
   J Cyst Fibros. 2010 May;9(3):193-8. Epub 2010 Mar 17.
3. Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity.
   Holder E, Stevenson B, Farley R, Hilliard T, Wodehouse T, Somerton L, Larsen M, O'Donoghue J, Coles RL, Scheule RK, Cheng SH, Gill DR, Hyde SC, Griesenbach U, Alton EW, Porteous DJ, Boyd AC.
   J Gene Med. 2010 Jan;12(1):55-63.PMID: 19937989
4. SELDI-TOF biomarker signatures for cystic fibrosis, asthma and chronic obstructive pulmonary disease.
   Gomes-Alves P, Imrie M, Gray RD, Nogueira P, Ciordia S, Pacheco P, Azevedo P, Lopes C, de Almeida AB, Guardiano M, Porteous DJ, Albar JP, Boyd AC, Penque D.
   Clin Biochem. 2010 Jan;43(1-2):168-77. Epub 2009 Oct 20.PMID: 19850022
5. Sputum trace metals are biomarkers of inflammatory and suppurative lung disease.
   Gray RD, Duncan A, Noble D, Imrie M, O'Reilly DS, Innes JA, Porteous DJ, Greening AP, Boyd AC.
   Chest. 2010 Mar;137(3):635-41. Epub 2009 Oct 3.PMID: 19801580
6. Limitations of the murine nose in the development of nonviral airway gene transfer.
   Griesenbach U, Sumner-Jones SG, Holder E, Munkonge FM, Wodehouse T, Smith SN, Wasowicz MY, Pringle I, Casamayor I, Chan M, Coles R, Cornish N, Dewar A, Doherty A, Farley R, Green AM, Jones BL, Larsen MD, Lawton AE, Manvell M, Painter H, Singh C, Somerton L, Stevenson B, Varathalingam A, Siegel C, Scheule RK, Cheng SH, Davies JC, Porteous DJ, Gill DR, Boyd AC, Hyde SC, Alton EW.
   Am J Respir Cell Mol Biol. 2010 Jul;43(1):46-54. Epub 2009 Jul 31.PMID: 19648474
7. An immunocytochemical assay to detect human CFTR expression following gene transfer.
   Davidson H, Wilson A, Gray RD, Horsley A, Pringle IA, McLachlan G, Nairn AC, Stearns C, Gibson J, Holder E, Jones L, Doherty A, Coles R, Sumner-Jones SG, Wasowicz M, Manvell M, Griesenbach U, Hyde SC, Gill DR, Davies J, Collie DD, Alton EW, Porteous DJ, Boyd AC.
   Mol Cell Probes. 2009 Dec;23(6):272-80. Epub 2009 Jul 15.PMID: 19615439
8. Assessment of CFTR function after gene transfer in vitro and in vivo.
   Griesenbach U, Munkonge FM, Sumner-Jones S, Holder E, Smith SN, Boyd AC, Gill DR, Hyde SC, Porteous D, Alton EW; UK Cystic Fibrosis Gene Therapy Consortium.
   Methods Mol Biol. 2008;433:229-42.PMID: 18679627
9. Tripod-like cationic lipids as novel gene carriers.
   Unciti-Broceta A, Holder E, Jones LJ, Stevenson B, Turner AR, Porteous DJ, Boyd AC, Bradley M.
   J Med Chem. 2008 Jul 24;51(14):4076-84. Epub 2008 Jun 26.PMID: 18578515
10. Sputum proteomics in inflammatory and suppurative respiratory diseases.
    Gray RD, MacGregor G, Noble D, Imrie M, Dewar M, Boyd AC, Innes JA, Porteous DJ, Greening AP.
    Am J Respir Crit Care Med. 2008 Sep 1;178(5):444-52. Epub 2008 Jun 19.PMID: 18565957
11. CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
    Hyde SC, Pringle IA, Abdullah S, Lawton AE, Davies LA, Varathalingam A, Nunez-Alonso G, Green AM, Bazzani RP, Sumner-Jones SG, Chan M, Li H, Yew NS, Cheng SH, Boyd AC, Davies JC, Griesenbach U, Porteous DJ, Sheppard DN, Munkonge FM, Alton EW, Gill DR.
    Nat Biotechnol. 2008 May;26(5):549-51. Epub 2008 Apr 27. Review.PMID: 18438402
12. Role of biophysical parameters on ex vivo and in vivo gene transfer to the airway epithelium by polyethylenimine/albumin complexes.
    Di Gioia S, Rejman J, Carrabino S, De Fino I, Rudolph C, Doherty A, Hyndman L, Di Cicco M, Copreni E, Bragonzi A, Colombo C, Boyd AC, Conese M.
    Biomacromolecules. 2008 Mar;9(3):859-66. Epub 2008 Feb 15.PMID: 18275149
13. Biomarkers for cystic fibrosis lung disease: application of SELDI-TOF mass spectrometry to BAL fluid.
    MacGregor G, Gray RD, Hilliard TN, Imrie M, Boyd AC, Alton EW, Bush A, Davies JC, Innes JA, Porteous DJ, Greening AP.
    J Cyst Fibros. 2008 Sep;7(5):352-8. Epub 2008 Feb 1.PMID: 18243068
14. Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR.
    Scott-Ward TS, Cai Z, Dawson ES, Doherty A, Da Paula AC, Davidson H, Porteous DJ, Wainwright BJ, Amaral MD, Sheppard DN, Boyd AC.
    Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16365-70. Epub 2007 Oct 3.PMID: 17913891
15. Genomic context vectors and artificial chromosomes for cystic fibrosis gene therapy.
    Conese M, Boyd AC, Di Gioia S, Auriche C, Ascenzioni F.
    Curr Gene Ther. 2007 Jun;7(3):175-87. Review. Erratum in: Curr Gene Ther. 2007 Aug;7(4):295. PMID: 17584036
16. Optimizing aerosol gene delivery and expression in the ovine lung.
    McLachlan G, Baker A, Tennant P, Gordon C, Vrettou C, Renwick L, Blundell R, Cheng SH, Scheule RK, Davies L, Painter H, Coles RL, Lawton AE, Marriott C, Gill DR, Hyde SC, Griesenbach U, Alton EW, Boyd AC, Porteous DJ, Collie DD.
    Mol Ther. 2007 Feb;15(2):348-54.PMID: 17235313
17. Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways.
    Davidson H, McLachlan G, Wilson A, Boyd AC, Doherty A, MacGregor G, Davies L, Painter HA, Coles R, Hyde SC, Gill DR, Amaral MD, Collie DD, Porteous DJ, Penque D.
    Am J Respir Cell Mol Biol. 2006 Jul;35(1):72-83. Epub 2006 Feb 23.PMID: 16498081