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Identification and Investigation of Variants Associated with Bipolar Disorder and Schizophrenia
Our Aims
- To identify genetic variants that increase susceptibility to schizophrenia, bipolar disorder and related phenotypes
- To study the functions of the genes encoding the variants and to determine how they cause susceptibility to illness
Projects
- Analysis of a susceptibility region for bipolar disorder on chromosome 4p
- Investigation of coding variants in the DISC1 gene identified by sequencing individuals with psychiatric illness
- Investigation of putative regulatory variants in the DISC1 gene identified by sequencing individuals with psychiatric illness
- Investigation of the Correlation between Endophenotypes of Working Memory and Expression Levels of DISC1 Pathway Genes
- Characterisation of differential expression in the presence of DISC1 mutations
Key Publications
- Christoforou A, McGhee KA, Morris SW, Thomson PA, Anderson S, McLean A, Torrance HS, Le Hellard S, Pickard BS, Stclair D, Muir WJ, Blackwood DH, Porteous DJ, Evans KL. (2010) Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p. Mol Psychiatry. Mar 30. [Epub ahead of print]
- Christoforou A, Le Hellard S, Thomson PA, Morris SW, Tenesa A, Pickard BS, Wray NR, Muir WJ, Blackwood DHR, Porteous DJ and Evans KL. (2007). Association analysis of the chromosome 4p15-16 candidate region for bipolar disorder and schizophrenia. Mol Psychiatry. 12:1011-25
- Le Hellard S, Underwood S, Lee AJ, Thomson PA, Morris SW, Torrance HS, Anderson SM, Adams RA, Navarro P, Christoforou A, Houlihan LM, Detera-Wadleigh S, Owen MJ, Asherson P, Muir WJ, Blackwood DHR, Wray NR, Porteous DJ and Evans KL. (2007). Haplotype and Allele Sharing Analysis of Chromosome 4p Linked Families with Bipolar Affective Disorder and Schizophrenia. Biol Psychiatry. 61: 797-805
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